منابع مشابه
Phenformin and lactic acidosis.
Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for la...
متن کاملPhenformin and pulmonary hypertension.
Two cases with clinical signs ofpulmonary hypertension and right heart failure developing during phenformin treatment are reported. The patients were clinically improved on withdrawal of phenformin. Two possible explanations for the pulmonary hypertension were considered: cellular anaerobiosis or alphareceptor stimulation of the pulmonary vessels. The 4 patients sofar reported direct attention ...
متن کاملPhenformin (Dibotin) in polyarthritis.
Since 1956 biguanides have received attention as oral hypoglycaemic agents (Krall and Bradley, 1959). Ungar, Madison, and Carter (1960), using phenformin (Dibotin, phenethyl biguanide), showed their effect on peripheral utilization of glucose, Butterfield, Fry, and Holling (1958) having previously demonstrated increased uptake of insulin in hepatic and peripheral tissues. Since then the drug ha...
متن کاملPhenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis).
sociated with albuminuria in type 2 diabetic patients (4). To the best of our knowledge, however, it is not clear whether serum homocysteine is associated with TNF receptor in type 2 diabetic patients. The aim of the present study was therefore to investigate the relationships between serum homocysteine and TNF receptor in patients with type 2 diabetes. Fifty nonobese Japanese type 2 diabetic p...
متن کاملSpironolactone and diabetic ketoacidosis.
Introduction Spironolactone is a specific competitive antagonist of aldosterone, the most potent endogenous mineralocorticoid, which modifies renal electrolyte handling and is therefore commonly used as a diuretic in conditions associated with secondary hyperaldosteronism. In renal insufficiency, aldosterone antagonists may induce significant hyperkalaemia even if administered concurrently with...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1961
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.10.4.321